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OCR: e world's lodine deficiency today remains one of t e years of most prevalent medical problems, despi iodinationeffort to correct the problem through sal dietary or iodinated oil injections. Reduction of iodine intake below the minimum daily rmone requirement leads to reduced thyroid ho in TSH production and a compensatory increase of T3 secretion. There is preferential secretion nd of the rather than T4. The frequency of goitre a to the occurrence of hypothyroidism is related oderate degree of iodine deficiency. In areas of m excretion endemic deficiency with urinary iodide evalence ofbetween 25 and 50ug/g creatinine, the p st all goitre is twenty to fifty per cent, but alm ith urinary individuals will be euthyroid, In areas w he Andes, iodide less than 25ug/g creatinine, as in valence Him ...